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KMID : 1007520140230051615
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Food Science and Biotechnology
2014 Volume.23 No. 5 p.1615 ~ p.1621
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Antioxidant Activity and Hepatoprotective Effect of Schizandra chinensis Baill. Extracts Containing Active Components in Alcohol-induced HepG2 Cells
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Sung Mi-sun
Park Sung-Sun
Kim Sung-Soo
Han Chan-Kyu
Hur Jung-Mu
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Abstract
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The antioxidant activities and hepatoprotective effects of Schizandra chinensis Baill. extracts (SCE) were evaluated. The contents of the active components schisandrin, schisandrin C, gomisin A, and gomisin N in SCE were 8.802±1.390, 1.011±0.203, 0.954±0.191, and 3.351±0.829 mg/g, respectively. The antioxidant activity of SCE was measured based on the DPPH free radical scavenging activity and the superoxide dismutase (SOD)-like activity. The IC50 values for the DPPH radical scavenging activity and SOD-like activity were 18.1 and 44.2mg/mL, respectively. The protective effect of SCE against alcohol-induced oxidative injury in HepG2 cells was investigated. Cells pretreated with SCE (100-400 μg/mL) showed an increased resistance to oxidative stress in a dose-dependent manner. Expressions of Bcl-2 and pro-caspase-3 proteins were induced by SCE in HepG2 cells. SCE can be useful for management of antioxidant and hepatoprotective effects.
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KEYWORD
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Schizandra chinensis Baill., antioxidant, hepatoprotective, alcohol injury
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